Scientists devise new strategy to destroy multiple myeloma

Public release date: 14-Aug-2012
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Contact: John Wallace
wallacej@vcu.edu
804-628-1550
Virginia Commonwealth University

Researchers at Virginia Commonwealth University Massey Cancer Center are reporting promising results from laboratory and animal experiments involving a new combination therapy for multiple myeloma, the second most common form of blood cancer.

The study published online in the journal Cancer Research details a dramatic increase in multiple myeloma cell death caused by a combination of the drugs obatoclax and flavopiridol. The researchers, led by Steven Grant, M.D., Shirley Carter Olsson and Sture Gordon Olsson Chair in Oncology Research, associate director for translational research, program co-leader and member of Developmental Therapeutics and member of the Cancer Cell Signaling program at VCU Massey Cancer Center, found that the two drugs worked together through different mechanisms to promote a form of cell suicide known as apoptosis.

"There is an urgent need for curative therapies for multiple myeloma," says Grant. "Our hope is that this research will lay the foundation for new and more effective treatments for patients with multiple myeloma and potentially other blood cancers for which adequate therapies are lacking."

Obatoclax is an experimental agent currently being investigated in various forms of blood cancers. It works by disabling proteins that prevent cancer cells from undergoing apoptosis. Flavopiridol is a member of a class of agents known as a cyclin-dependant kinase (CDK) inhibitors, and blocks the growth of cancer cells in addition to reducing levels of anti-apoptotic proteins.

In laboratory experiments, the novel drug combination dramatically increased multiple myeloma cell death. These results were confirmed in animal models where the drugs significantly improved the survival of immune-compromised mice with human multiple myeloma. An unexpected effect was also observed flavopiridol, in addition to reducing levels of anti-apoptotic proteins, significantly increased the expression of apoptosis-inducing proteins such as Bim, a protein shown in previous studies to trigger cell death.

"This research builds on nearly a decade of work carried out by our laboratory that focuses on manipulating mechanisms that lead to apoptosis in hematological malignancies," says Grant. "Our findings could have immediate implications for the design of clinical trials using combinations of these types of drugs. In fact, plans to develop such a trial at Massey are currently underway."

Because the findings showed synergism between these two classes of drugs, the researchers plan to test other clinically-relevant CDK inhibitors in combination with obatoclax for multiple myeloma.

###

Grant collaborated with the study's lead co-authors, Yun Dai, M.D., Ph.D., and Shuang Chen, M.D., Ph.D., from the VCU Department of Internal Medicine, who were key contributors to this work. Other collaborators included Xinyan Pei, M.D., Ph.D., also from the VCU Department of Internal Medicine; Paul Dent, Ph.D., Universal Corporation distinguished professor in cancer cell signaling and member of the Developmental Therapeutics program at VCU Massey; and Robert Orlowski, Ph.D., M.D., from M.D. Anderson Cancer Center.

The full manuscript of this study can be found at: http://cancerres.aacrjournals.org/content/early/2012/06/14/0008-5472.CAN-12-1118.long

This research was supported by NIH Research Project Grant (RO1) CA100866, a Multiple Myeloma SPORE award from the National Cancer Institute, the Multiple Myeloma Research Foundation, the Leukemia and Lymphoma Society of America and, in part, by funding from VCU Massey Cancer Center's NIH-NCI Cancer Center Support Grant P30 CA016059.

News directors: Broadcast access to VCU Massey Cancer Center experts is available through VideoLink ReadyCam. ReadyCam transmits video and audio via fiber optics through a system that is routed to your newsroom. To schedule a live or taped interview, contact John Wallace, (804) 628-1550.

About VCU Massey Cancer Center

VCU Massey Cancer Center is one of only 67 National Cancer Institute-designated institutions in the country that leads and shapes America's cancer research efforts. Working with all kinds of cancers, the Center conducts basic, translational and clinical cancer research, provides state-of-the-art treatments and clinical trials, and promotes cancer prevention and education. Since 1974, Massey has served as an internationally recognized center of excellence. It has one of the largest offerings of clinical trials in Virginia and serves patients in Richmond and in five satellite locations. Its 1,000 researchers, clinicians and staff members are dedicated to improving the quality of human life by developing and delivering effective means to prevent, control and ultimately to cure cancer. Visit Massey online at www.massey.vcu.edu or call 877-4-MASSEY for more information.

About VCU and the VCU Medical Center

Virginia Commonwealth University is a major, urban public research university with national and international rankings in sponsored research. Located on two downtown campuses in Richmond, VCU enrolls more than 32,000 students in 211 certificate and degree programs in the arts, sciences and humanities. Sixty-nine of the programs are unique in Virginia, many of them crossing the disciplines of VCU's 13 schools and one college. MCV Hospitals and the health sciences schools of Virginia Commonwealth University compose the VCU Medical Center, one of the nation's leading academic medical centers. For more, see www.vcu.edu.

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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Public release date: 14-Aug-2012
[ | E-mail | Share ]

Contact: John Wallace
wallacej@vcu.edu
804-628-1550
Virginia Commonwealth University

Researchers at Virginia Commonwealth University Massey Cancer Center are reporting promising results from laboratory and animal experiments involving a new combination therapy for multiple myeloma, the second most common form of blood cancer.

The study published online in the journal Cancer Research details a dramatic increase in multiple myeloma cell death caused by a combination of the drugs obatoclax and flavopiridol. The researchers, led by Steven Grant, M.D., Shirley Carter Olsson and Sture Gordon Olsson Chair in Oncology Research, associate director for translational research, program co-leader and member of Developmental Therapeutics and member of the Cancer Cell Signaling program at VCU Massey Cancer Center, found that the two drugs worked together through different mechanisms to promote a form of cell suicide known as apoptosis.

"There is an urgent need for curative therapies for multiple myeloma," says Grant. "Our hope is that this research will lay the foundation for new and more effective treatments for patients with multiple myeloma and potentially other blood cancers for which adequate therapies are lacking."

Obatoclax is an experimental agent currently being investigated in various forms of blood cancers. It works by disabling proteins that prevent cancer cells from undergoing apoptosis. Flavopiridol is a member of a class of agents known as a cyclin-dependant kinase (CDK) inhibitors, and blocks the growth of cancer cells in addition to reducing levels of anti-apoptotic proteins.

In laboratory experiments, the novel drug combination dramatically increased multiple myeloma cell death. These results were confirmed in animal models where the drugs significantly improved the survival of immune-compromised mice with human multiple myeloma. An unexpected effect was also observed flavopiridol, in addition to reducing levels of anti-apoptotic proteins, significantly increased the expression of apoptosis-inducing proteins such as Bim, a protein shown in previous studies to trigger cell death.

"This research builds on nearly a decade of work carried out by our laboratory that focuses on manipulating mechanisms that lead to apoptosis in hematological malignancies," says Grant. "Our findings could have immediate implications for the design of clinical trials using combinations of these types of drugs. In fact, plans to develop such a trial at Massey are currently underway."

Because the findings showed synergism between these two classes of drugs, the researchers plan to test other clinically-relevant CDK inhibitors in combination with obatoclax for multiple myeloma.

###

Grant collaborated with the study's lead co-authors, Yun Dai, M.D., Ph.D., and Shuang Chen, M.D., Ph.D., from the VCU Department of Internal Medicine, who were key contributors to this work. Other collaborators included Xinyan Pei, M.D., Ph.D., also from the VCU Department of Internal Medicine; Paul Dent, Ph.D., Universal Corporation distinguished professor in cancer cell signaling and member of the Developmental Therapeutics program at VCU Massey; and Robert Orlowski, Ph.D., M.D., from M.D. Anderson Cancer Center.

The full manuscript of this study can be found at: http://cancerres.aacrjournals.org/content/early/2012/06/14/0008-5472.CAN-12-1118.long

This research was supported by NIH Research Project Grant (RO1) CA100866, a Multiple Myeloma SPORE award from the National Cancer Institute, the Multiple Myeloma Research Foundation, the Leukemia and Lymphoma Society of America and, in part, by funding from VCU Massey Cancer Center's NIH-NCI Cancer Center Support Grant P30 CA016059.

News directors: Broadcast access to VCU Massey Cancer Center experts is available through VideoLink ReadyCam. ReadyCam transmits video and audio via fiber optics through a system that is routed to your newsroom. To schedule a live or taped interview, contact John Wallace, (804) 628-1550.

About VCU Massey Cancer Center

VCU Massey Cancer Center is one of only 67 National Cancer Institute-designated institutions in the country that leads and shapes America's cancer research efforts. Working with all kinds of cancers, the Center conducts basic, translational and clinical cancer research, provides state-of-the-art treatments and clinical trials, and promotes cancer prevention and education. Since 1974, Massey has served as an internationally recognized center of excellence. It has one of the largest offerings of clinical trials in Virginia and serves patients in Richmond and in five satellite locations. Its 1,000 researchers, clinicians and staff members are dedicated to improving the quality of human life by developing and delivering effective means to prevent, control and ultimately to cure cancer. Visit Massey online at www.massey.vcu.edu or call 877-4-MASSEY for more information.

About VCU and the VCU Medical Center

Virginia Commonwealth University is a major, urban public research university with national and international rankings in sponsored research. Located on two downtown campuses in Richmond, VCU enrolls more than 32,000 students in 211 certificate and degree programs in the arts, sciences and humanities. Sixty-nine of the programs are unique in Virginia, many of them crossing the disciplines of VCU's 13 schools and one college. MCV Hospitals and the health sciences schools of Virginia Commonwealth University compose the VCU Medical Center, one of the nation's leading academic medical centers. For more, see www.vcu.edu.

---

[ | E-mail | Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

Source: http://www.eurekalert.org/pub_releases/2012-08/vcu-sdn081412.php

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What Is The Purpose Of The Room That you Are About To Decorate ...

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Is TrapWire surveillance spying on Americans?

14 hrs.

Paul Wagenseil, SecurityNewsDaily Managing Editor

WikiLeaks is under attack again, and many Internet users speculate it may be related to information the site has recently published about a wide-spanning American surveillance system called TrapWire.

"What is TrapWire and why is WikiLeaks under a sophisticated DDOS attack after posting docs about TrapWire?" tweeted journalist, professor and media critic Dan Gillmor Friday.

"What does it mean when WikiLeaks publishes a trove of documents hacked by Anonymous from the strategic intelligence firm Stratfor ? a trove that apparently details a massive electronic spying system run by the U.S. government ? and is then hit by a massive and sustained distributed denial of service attack that prevents journalists and people at large from examining the documents in question?" wondered blogger J.D Tuccille on the libertarian Reason.com website. "I can't be the only person that finds that just a tad ... suggestive."

TrapWire itself is being touted as Big Brother, a hidden means to keep track of every citizen in once-free countries. There are allegations that it uses facial-recognition technology to identify suspects, and that it's been installed in most cities in North America.

"Surveillance Cameras Around The Country Are Being Used In A Huge Spy Network" read a headline on the Business Insider website Friday. "Stratfor emails reveal secret, widespread TrapWire surveillance system," said Russia Today.

"The government has created a piece of technology, called TrapWire, that siphons data from surveillance cameras in stores, casinos and other businesses around the country," wrote Annalee Newitz on the science-fiction blog io9. "Are we living in a total surveillance state without even realizing it?"

Sunday, Anonymous got into the act by announcing "Operation Trapwire," urging followers to "shut this system down and render it useless."

"A giant AI electronic brain able to monitor us through a combination of access to all the CCTV cameras as well as all the online social media feeds is monstrous and Orwellian in its implications and possibilities," read the Anonymous press release.

And Monday, the London Daily Mail told the world that the "U.S. government is secretly spying on EVERYONE using civilian security cameras."

Emails to TrapWire, Inc., and Strategic Forecasting, Inc., aka Stratfor, were not immediately returned.

[ 10 Ways the Government Watches You ]

Hold on, everyone
There are just two problems with this scenario. First, the distributed denial-of-service (DDoS) attack on WikiLeaks began more than a week ago, on Aug. 3, before WikiLeaks and other sites first posted information regarding TrapWire on Aug. 8.

"We are not doing this to call attention to ourselves," wrote AntiLeaks, a hacker group claiming responsibility for the DDoS attack. "We are young adults, citizens of the United States of America and are deeply concerned about the recent developments with [WikiLeaks leader] Julian Assange and his attempt at asylum in Ecuador. Assange is the head of a new breed of terrorist. We are doing this as a protest against his attempt to escape justice into Ecuador."

Could it be that someone outside WikiLeaks was tipped off that the TrapWire information would be coming out?

"It's possible that [former TrapWire owner] Abraxas et al. got word that Wikileaks was to be publishing info on TrapWire," former Anonymous spokesman Barrett Brown told SecurityNewsDaily. "It's impossible for anyone to say what methods of surveillance or even HUMINT [human intelligence] WikiLeaks and its people are subjected to. But I'll remain agnostic on the issue until I see any evidence of this, as coincidence is always possible."

The second problem is that TrapWire is no secret, it's not run by the government and it's not everywhere. The Reston, Va.-based company behind it, now also called TrapWire, is happy to tell people what it does.

"TrapWire is a unique, predictive software system designed to detect patterns indicative of terrorist attacks or criminal operations," reads a page on the TrapWire website. "Utilizing a proprietary, rules-based engine, TrapWire detects, analyzes and alerts on suspicious events as they are collected over periods of time and across multiple locations.

"Through the systematic capture of these pre-attack indicators, terrorist or criminal surveillance and pre-attack planning operations can be identified ? and appropriate law enforcement counter measures employed ahead of the attack."

In plain English, TrapWire collects and analyzes surveillance-camera footage as part of counterterrorist efforts.

Laying it all out
Two executives at Abraxas Corp., TrapWire's former owner, wrote an article for the November/December 2006 issue of Crime and Justice International magazine explaining the system. Brochures describing the system can be found online. An Abraxas patent filing for the TrapWire system is a matter of public record.

The patent filing explains that TrapWire is meant to catch potential terrorists conducting their own surveillance and reconnaissance missions on public facilities.

"While international terrorist organizations are using increasingly sophisticated methods, their modus operandi does contain a critical vulnerability: meticulous pre-attack preparations require the terrorists to approach a target facility on multiple occasions to identify and physical and procedural vulnerabilities, probe for weaknesses and conduct practice missions," the patent filing reads.

"TrapWire is specifically designed to exploit this vulnerability by combining deep counterterrorism experience, proven counter-surveillance techniques, unique sensor systems and data mining capabilities to detect attack preparations and allow security personnel to deter or intercept terrorists."

Eyes without a face
While the TrapWire company doesn't disclose who its clients are (its website took down a page detailing its executives' ties to the CIA), it's easy to find some of them.

The minutes of a New Jersey Transit board meeting in November 2011 reveal that a board member recommended the transit authority adopt the system, since it was already being used by the neighboring Metropolitan Transit Authority, which runs the New York City subway and bus systems and operates several commuter railroads.

(Last week, the New York Police Department revealed that already has an even more sophisticated surveillance system in place, which it developed with Microsoft.)

Other TrapWire clients include the Las Vegas Police Department, which provided the software to more than a dozen casinos and, according to Stratfor emails leaked by WikiLeaks, the Los Angeles and Washington, D.C., police departments and the Texas Department of Public Safety.

"It's also been used in London for a while," said Brown, who's been collecting information on Internet-based government surveillance efforts.

Nor is there firm evidence that TrapWire collects facial recognition data. As Internet muckraker Ben Doernberg found in an article dispelling some of the rumors, TrapWire's owners think they don't need it. (PrivacySOS, run by the Massachusetts branch of the ACLU, ran a similar debunking story.)

"The nuclear industry has 104 civilian owned and operated nuclear power plants, and yet they don?t collect or share pre-attack information," Abraxas founder and retired CIA officer Richard "Hollis" Helms told the Northern Virginia Technology Council in 2007. "TrapWire can help do that without infringing anyone's civil liberties. It can collect information about people and vehicles that is more accurate than facial recognition, draw patterns, and do threat assessments of areas that may be under observation from terrorists."

Two months ago, TrapWire updated its own privacy policy, and reiterated that it doesn't collect data on private citizens.

"Generally, no Personal Information or Sensitive Personal Information is recorded by the TrapWire system, and no such information is used by the system to perform its various functions," read the policy paper.

"In the event a system user were to enter either Personal Information or Sensitive Personal Information in a comments field, TrapWire will not share or expose that information to any other subscriber on the system, unless required by law, and, in any case, will otherwise adhere to Safe Harbor Privacy Principles with respect to that information."

The real problems: past, present and future
Whether or not TrapWire's operators are telling the truth about its capabilities is up to the conspiracy theorists, and the lawyers, to decide.

The real scandal, buried beneath the hype, may be that Stratfor seems to have acted as a front man for Abraxas in exchange for a percentage of sales. Stratfor's other clients might not be happy to learn that the firm may be working for a competitor.

"TrapWire for the Great State of Texas is a go. Cash should begin to flow to Abraxas within 10 days," allegedly wrote former Stratfor chief executive officer Fred Burton in an email dated July 16, 2009. "As many of you old-timers know, we arranged to get a cut. I think the first dump is $250,000 to Abraxas, with an annual renewal of $150,000 per year for the TrapWire license."

"TrapWire may be the most successful invention on the GWOT [global war on terrorism] since 9-11," Burton added. "I knew these hacks when they were GS-12's [mid-salaried federal employees] at the CIA. God Bless America. Now they have EVERY major HVT [high-value target] in CONUS [continental U.S.], the UK, Canada, Vegas, Los Angeles, NYC as clients."

(Later in 2009, Burton left Stratfor to take a position with the Texas Department of Public Safety. He has since returned to Stratfor as its vice president of intelligence.)

In any case, Anonymous has geared up for action.

"We will find, hack ? and destroy the servers where the AI 'electronic brain' of this program is housed," read Sunday's Anonymous press release.

It hinted at an action called "Smash a Cam Saturday," though it did not give the date when Guy Fawkes-masked vigilantes should take baseball bats to security cameras.

"TrapWire has access to virtually all CCTV's that have IP/internet connectivity," the press release said. "We have prepared an initial map/database of these cameras across the USA, and we will continue to expand this knowledge base."

"I gather that they intend for every Saturday to be sort of camera-smashing holiday," Brown said.?

More from SecurityNewsDaily:

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BBC shows off 33-megapixel Super Hi-Vision Olympic footage, we ask: why?

The first live Super Hi-Vision broadcast for public consumption was of the Olympic opening ceremony in London last week. We didn't get to see that premiere, or the second or third screenings either -- but the fourth? Oh yes. We grabbed a seat right up front of a small theater inside BBC Broadcasting House, watched a live 33-megapixel feed from the Aquatics Center and absorbed some very fond memories in the process. At the same time, a question hung over the footage like a watermark: why bother? The world is barely getting to grips with the notion of 4K, so why did the BBC and Japanese broadcaster NHK go to the expense of sending a dedicated SHV video truck, a 22.2-channel SHV audio truck, and the world's only three 8K Ultra HDTV cameras to London? Fortunately, we caught up with someone in charge who was able to respond to that question. Read on for what they said, plus a slightly fuller sense of what the footage was like to watch.

Continue reading BBC shows off 33-megapixel Super Hi-Vision Olympic footage, we ask: why?

Filed under: Displays, Home Entertainment

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